LB-100, CAS 1632032-53-1

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: (1R,4S)-rel-3-[(4-methyl-1-piperazinyl)carbonyl]-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid

Purity: ≥98%

Formula Markup: C13H20N2O4

Formula Weight: 268.30898

CAS Number: 1632032-53-1

Notes: LB-100 is an inhibitor of protein phosphatase 2A (PP2A) with anticancer activity.{46518} It reduces PP2A activity and is cytotoxic to BxPC-3 and PANC-1 cells (IC50s = 0.85 and 3.87 μM, respectively). LB-100 inhibits radiation-induced Rad51 focus formation and homologous recombination repair in PANC-1 and MiaPaCa-2 cells.{46519} In vivo, it increases tumor microvessel density and VEGF secretion and decreases tumor volume in a PANC-1 mouse xenograft model when administered at a dose of 2 mg/kg.{46518} LB-100 (1.5 mg/kg) enhances radiation-induced reductions in tumor volume in CNE1 and CNE2 radioresistant nasopharyngeal carcinoma mouse xenograft models.{46520}

• SKU: CAY29105-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 29105-5
• Package Unit: 5 mg
• Quantity Unit: STK