LDN-212854, CAS 1432597-26-6

Product Description: LDN-212854 is a bone morphogenetic protein (BMP) inhibitor that potently inhibits ALK2 (IC50: 1.3 nM). LDN-212854 also inhibits ALK1 (IC50: 2.40 nM). LDN-212854 can be used in the research of fibrodysplasia ossificans progressive and cancers, such as hepatocellular carcinoma (HCC)[1][2].

Applications: Cancer-Kinase/protease

Formula: C25H22N6

References: [1]Mohedas AH, et al. Development of an ALK2-biased BMP type I receptor kinase inhibitor. ACS Chem Biol. 2013;8(6):1291-302./[2]Han Chen, et al. BMP9-ID1 signaling promotes EpCAM-positive cancer stem cell properties in hepatocellular carcinoma. Mol Oncol. 2021 Aug;15(8):2203-2218.

CAS Number: 1432597-26-6

Molecular Weight: 406.48

Compound Purity: 99.70

Research Area: Cancer

Solubility: DMSO : ≥ 30 mg/mL

Target: TGF-β Receptor

• SKU: MEXHY-15897-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-15897-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK