Product Description: LDN-27219 is a reversible, slow-binding inhibitor of TGase. LDN-27219 inhibits human TGase with an IC50 value of 0.6 μM. LDN-27219 effectively decreases blood pressure and induces vasodilation, it can be used for the research of cardiovascular disease[1][2].
Formula: C20H16N4O2S2
References: [1]Case A, et al. Kinetic analysis of the interaction of tissue transglutaminase with a nonpeptidic slow-binding inhibitor. Biochemistry. 2007 Jan 30;46(4):1106-15./[2]Pinilla E, et al. Transglutaminase 2 Inhibitor LDN 27219 Age-Dependently Lowers Blood Pressure and Improves Endothelium-Dependent Vasodilation in Resistance Arteries. Hypertension. 2021 Jan;77(1):216-227.
CAS Number: 312946-37-5
Molecular Weight: 408.50
Compound Purity: 99.64
Research Area: Others; Cardiovascular Disease
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: Others
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