Product Description: LDN-57444 is a reversible, competitive and site-directed inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1), with an IC50 of 0.88 μM and a Ki of 0.40 μM; LDN-57444 also suppresses UCH-L3 activity, with an IC50 of 25 μM.
Applications: Neuroscience-Neurodegeneration
Formula: C17H11Cl3N2O3
References: [1]Liu Y, et al. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol. 2003 Sep;10(9):837-46./[2]Gong B, et al. Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory. Cell. 2006 Aug 25;126(4):775-88./[3]Tan YY, et al. Endoplasmic reticulum stress contributes to the cell death induced by UCH-L1 inhibitor. Mol Cell Biochem. 2008 Nov;318(1-2):109-15.
CAS Number: 668467-91-2
Molecular Weight: 397.64
Compound Purity: 98.93
Research Area: Neurological Disease
Solubility: DMSO : 25 mg/mL (ultrasonic)
Target: Apoptosis;Deubiquitinase
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