LE 135, CAS 155877-83-1

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 4-(7,8,9,10-tetrahydro-5,7,7,10,10-pentamethyl-5H-benzo[e]naphtho[2,3-b][1,4]diazepin-13-yl)-benzoic acid

Purity: ≥98%

Formula Markup: C29H30N2O2

Formula Weight: 438.6

CAS Number: 155877-83-1

Notes: LE 135 is a retinoic acid receptor (RAR) antagonist that displays moderate selectivity for RARβ over RARα (Kis = 0.22 and 1.4 μM, respectively).{23265,23266} LE 135 inhibits retinoic acid-induced transcriptional activation of RARβ (>70% inhibition at 10 μM), but not RARα, RARγ or retinoid X receptor α.{23265} It has been shown to inhibit retinoid Am80-induced differentiation of human promyelocytic leukemia cells, HL-60, with an IC50 value of 0.2 μM.{23076}

• SKU: CAY14415-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 14415-5
• Package Unit: 5 mg
• Quantity Unit: STK