Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N-phenyl-4-[[(phenylamino)thioxomethyl]amino]-benzenesulfonamide
Purity: ≥98%
Formula Markup: C19H17N3O2S2
Formula Weight: 383.5
CAS Number: 245342-14-7
Notes: Bacterial pathogens require the conserved membrane histidine sensor kinase (QseC) to detect both host-derived adrenergic signals and the bacterial autoinducer-3 (AI-3), thus activating a signaling cascade that induces virulence gene expression.{16849} LED209 is a potent QseC inhibitor that blocks both norepinephrine- and epinephrine-triggered QseC-dependent virulence gene expression at 5 pM in vitro.{16355} While LED209 inhibits virulence of enterohemorrhagic E. coli, S. typhimurium, and F. tularensis, it does not inhibit pathogen growth, a highly desirable feature of antimicrobial agents to prevent drug resistance.{16355}
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