Product Description: Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle[1].
Applications: Cancer-programmed cell death
Formula: C33H48O6
References: [1]N Kudo, et al. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9112-7./[2]Sarah C Mutka,et al. Identification of nuclear export inhibitors with potent anticancer activity in vivo. Cancer Res. 2009 Jan 15;69(2):510-7./[3]Zhongwei Liu, et al.Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27./[4]Sarah C Mutka, et al. Identification of nuclear export inhibitors with potent anticancer activity in vivo. Cancer Res. 2009 Jan 15;69(2):510-7.
CAS Number: 87081-35-4
Molecular Weight: 540.73
Compound Purity: 99.94
Research Area: Cancer; Infection
Solubility: DMSO : ≥ 100 mg/mL/H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Antibiotic;CRM1;Fungal
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