Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N-acetyl-L-leucyl-N-[4-[(aminoiminomethyl)amino]-1S-formylbutyl]-L-leucinamide, hemisulfate
Purity: ≥90%
Formula Markup: C20H38N6O4 / 1/2H2SO4
Formula Weight: 475.6
CAS Number: 103476-89-7
Notes: Leupeptin is a reversible inhibitor of cysteine, serine, and threonine proteases that is produced naturally by Streptomyces.{22713} It has been reported to inhibit cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin.{22713} Leupeptin has been shown to be protective of auditory hair cells exposed to disruptive noise or ototoxic aminoglycoside-type antibiotics.{23480,23481} It is also widely used as a protein purification tool to prevent proteases present in tissue samples from degrading the protein of interest.
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