Product Description: Levofloxacin ((-)-Ofloxacin) hydrochloride is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin hydrochloride inhibits the DNA gyrase and topoisomerase IV. Levofloxacin hydrochloride can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin hydrochloride shows anti-orthopoxvirus activity[1][2][3][4][5].
Applications: COVID-19-anti-virus
Formula: C18H21ClFN3O4
Citations: Emerg Microbes Infect. 2024 Dec;13(1):2321981./ACS Infect Dis. 2024 Apr 12;10(4):1327-1338./AMB Express. 2024 Dec 24;14(1):141./Antibiotics (Basel). 2022, 11(2), 192./Antimicrob Agents Chemother. 2021 Feb 17;65(3):e01921-20./bioRxiv. 2024 May 10./bioRxiv. 2025 January 19./Cell Rep Methods. 2023 Oct 23;3(10):100599./Chin J Traumatol. 2024 Jul 3:S1008-1275(24)00075-0./Clin Chem. 2019 Dec;65(12):1522-1531. /PLoS One. 2024 Apr 18;19(4):e0298577./Results Chem. 2024 Oct./Toxics. 2025 Feb 5./Nat Commun. 2022 Mar 2;13(1):1116.
References: [1]Siva, R., et al., Effect of levofloxacin on neutrophilic airway inflammation in stable COPD: a randomized, double-blind, placebo-controlled trial. Int J Chron Obstruct Pulmon Dis, 2014. 9: p. 179-86./[2]Pradeep, A.R., et al., Clinical and microbiological effects of levofloxacin in the treatment of chronic periodontitis: a randomized, placebo-controlled clinical trial. J Investig Clin Dent, 2014./[3]Lee, B.T., et al., Efficacy of Levofloxacin in the Treatment of BK Viremia: A Multicenter, Double-Blinded, Randomized, Placebo-Controlled Trial. Clin J Am Soc Nephrol, 2014./[4]Drlica K, et al. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92. /[5]Smee DF, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57(1-2):41-52.
CAS Number: 177325-13-2
Molecular Weight: 397.83
Compound Purity: 98.0
Research Area: Infection; Cancer
Solubility: H2O : 20 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Antibiotic;Bacterial;DNA/RNA Synthesis;Orthopoxvirus;Topoisomerase
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