Lexibulin (Standard), CAS 917111-44-5

Product Description: Lexibulin (Standard) is the analytical standard of Lexibulin. This product is intended for research and analytical applications. Lexibulin (CYT-997) is a potent and orally active tubulin polymerisation inhibitor with IC50s of 10-100 nM in cancer cell lines; with potent cytotoxic and vascular disrupting activity in vitro and in vivo[1][2]. Lexibulin induces cell apoptosis and induces mitochondrial ROS generation in GC cells[3].

Formula: C24H30N6O2

References: [1]Burns CJ, et al. CYT997: a novel orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo. Mol Cancer Ther. 2009 Nov;8(11):3036-45./[2]Monaghan K, et al. CYT997 causes apoptosis in human multiple myeloma. Invest New Drugs. 2011 Apr;29(2):232-8./[3]Ya Cao, wt al. Mitochondrial ROS Accumulation Inhibiting JAK2/STAT3 Pathway Is a Critical Modulator of CYT997-induced Autophagy and Apoptosis in Gastric Cancer. J Exp Clin Cancer Res. 2020 Jun 23;39(1):119.

CAS Number: 917111-44-5

Molecular Weight: 434.53

Research Area: Cancer

Target: Apoptosis;Microtubule/Tubulin;Reactive Oxygen Species;Reference Standards

• SKU: MEXHY-10498R-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-10498R-0
• Package Unit: Get quote
• Quantity Unit: STK