Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 11a,15S-dihydroxy-17S,20-dimethyl-9-oxo-prosta-2E,13E-dien-1-oic acid
Purity: ≥98%
Formula Markup: C22H36O5
Formula Weight: 380.5
CAS Number: 74397-12-9
Notes: Limaprost is an analog of PGE1 with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is orally active in both rats and guinea pigs at doses of 100 µg/kg as an inhibitor of ADP and collagen induced platelet aggregation. Limaprost is 10-1,000 times more potent than PGE1 as an inhibitor of platelet adhesiveness measured in vitro. Intra-coronary injection (100 ng/kg) or intravenous injection (3 µg/kg) in anesthetized dogs causes vasodilation and increased coronary blood flow by 60-80%. Significant hypotensive effects were seen at 100 and 300 µg/kg orally in rats.{6808}
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