LJH685, CAS 1627710-50-2

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 2,6-difluoro-4-[4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl]-phenol

Purity: ≥98%

Formula Markup: C22H21F2N3O

Formula Weight: 381.4

CAS Number: 1627710-50-2

Notes: LJH685 is an inhibitor of p90 ribosomal S6 kinases (RSKs, also known as MAP kinase-activated protein kinases, or MAPKAPKs) that inhibits RSK1, 2, and 3 in vitro with IC50 values of 6, 5, and 4 nM, respectively.{33573} It is selective for RSKs over a panel of 96 other kinases. LJH685 blocks RSK activity in cells, preventing phosphorylation of y-box-binding protein 1 on Ser102.{33573} The inhibition of RSK activity correlates with antiproliferative effects in MAPK pathway-dependent cancer cell lines, but only in an anchorage-independent growth setting.{33573}

• SKU: CAY19913-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 19913-25
• Package Unit: 25 mg
• Quantity Unit: STK