Product Description: LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity[1].
Applications: Cancer-programmed cell death
Formula: C24H25ClN2O7
References: [1]Antony S, et al. Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison. Mol Pharmacol. 2005 Feb;67(2):523-30./[2]Antony S, et al. Bisindenoisoquinoline bis-1,3-{( 5,6-dihydro-5,11-diketo-11H-indeno [1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity. Mol Pharmacol. 2006 Sep;70(3):1109-20.
CAS Number: 308246-57-3
Molecular Weight: 488.92
Compound Purity: 99.70
Research Area: Cancer
Solubility: DMSO : 105 mg/mL (ultrasonic)
Target: Topoisomerase
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