LMW-PTP Inhibitor I (hydrochloride), CAS 2310135-46-5

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N,N-diethyl-4-[4-[[3-(1-piperidinyl)propyl]amino]-2-quinolinyl]-benzamide, dihydrochloride

Purity: ≥98%

Formula Markup: C28H36N4O / 2HCl

Formula Weight: 517.53308

CAS Number: 2310135-46-5

Notes: LMW-PTP inhibitor I (hydrochloride) is an inhibitor of low molecular weight phosphotyrosine protein phosphatase A (LMW-PTPA; IC50 = 0.8 µM).{34480} It is selective for LMW-PTPA over a panel of 15 protein tyrosine phosphatases but does inhibit LMW-PTPB activity by greater than 50% at 40 µM. LMW-PTP inhibitor I (hydrochloride) increases insulin-induced insulin receptor phosphorylation in HepG2 cells when used at a concentration of 10 µM. It improves glucose tolerance and decreases fasting plasma insulin levels in a mouse model of diet-induced obesity when administered at a dose of 50 mg/kg per day.

• SKU: CAY22277-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 22277-1
• Package Unit: 1 mg
• Quantity Unit: STK