Shelf life (days): 1825.0
Formulation: A crystalline solid
Formal Name: 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutanamide, monohydrochloride
Purity: ≥98%
Formula Markup: C29H33ClN2O2 / HCl
Formula Weight: 513.5
CAS Number: 34552-83-5
Notes: Loperamide is an opiate which potently and selectively activates μ opioid receptors (Ki = 0.16 nM) exclusively in the periphery. Loperamide is an opiate which potently and selectively activates μ opioid receptors (Ki = 0.16 nM) exclusively in the periphery.{23761,23758} It is a much weaker agonist of the δ opioid receptor (Ki = 50 nM).{23761} Through its actions in the gut wall, loperamide has antidiarrheal action by increasing transit time and by altering intestinal transport of water and electrolytes.{23758,23756} It also blocks voltage-sensitive sodium channels (IC50 = 270 nM) and high voltage-activated calcium channels (IC50 = 900 nM), presumably through an inhibitory effect on calmodulin.{23759,23760,23758} Loperamide is comparable to morphine in blocking peripheral pain in rats.{23757}
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