Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 6-chloro-4-hydroxy-2-methyl-N-2-pyridinyl-d4-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide-1,1-dioxide
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C13H6ClD4N3O4S2
Formula Weight: 375.84526
CAS Number: 1216527-48-8
Notes: Lornoxicam-d4 is intended for use as an internal standard for the quantification of lornoxicam (Item No. 70220) by GC- or LC-MS. Lornoxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties.{7909} It inhibits production of thromboxane B2 (TXB2; Item No. 19030) from arachidonic acid (Item Nos. 90010 / 90010.1 / 10006607) in HEL human erythroleukemic cells (IC50 = 3 nM), which endogenously express COX-1, as well as inhibits LPS-induced formation of prostaglandin F1α (PGF1α; Item No. 15010) from arachidonic acid in Mono-Mac-6 cells (IC50 = 8 nM), which endogenously express COX-2. Lornoxicam reduces LPS-induced production of nitric oxide and IL-6 in cell-based assays with IC50 values of 65 and 54 µM, respectively. It reduces carrageenan-induced paw edema in rats when administered intravenously at doses ranging from 0.1 to 9 mg/kg.{54733} Formulations containing lornoxicam have been used in the management of postoperative pain.
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