LRP5 blocking peptide

Species: Human

Specificity/Sensitivity: The peptide was used in the production of GTX89521.

Form: Lyophilized powder

Buffer (with preservative): Reconstitute with 200μl distilled water to obtain a 0.5mg/ml peptide solution. Lyophilized from 5% (v/v) acetonitrile/H₂O, no preservative.

Background: This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Region Sequence: C-ERVEKTTGDKRT

Full Name: LDL receptor related protein 5

• SKU: GTX89521-PEP-100
• Manufacturer: GeneTex
• Manufacturer SKU: GTX89521-PEP-100
• Package Unit: 100 μg
• Quantity Unit: STK
• Human Gene ID: 4041