LS-102, CAS 1456891-34-1

Product Description: LS-102 is a selective E3 ubiquitin ligase synoviolin (Syvn1) inhibitor. LS-102 inhibits the autoubiquitination of synoviolin with an IC50 of 35 μM. LS-102 has the potential for rheumatoid arthritis treatment[1][2].

Applications: COVID-19-immunoregulation

Formula: C24H36N8O

References: [1]Fujita H, et al. Identification of the inhibitory activity of walnut extract on the E3 ligase Syvn1. Mol Med Rep. 2018 Dec;18(6):5701-5708./[2]Yagishita N, et al. RING-finger type E3 ubiquitin ligase inhibitors as novel candidates for the treatment of rheumatoidarthritis. Int J Mol Med. 2012 Dec;30(6):1281-6.

CAS Number: 1456891-34-1

Molecular Weight: 452.60

Compound Purity: 97.92

Research Area: Inflammation/Immunology

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: E1/E2/E3 Enzyme

• SKU: MEXHY-135844-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-135844-5
• Package Unit: 5 mg
• Quantity Unit: STK