Lumacaftor, CAS 936727-05-8

Product Description: Lumacaftor (VX-809; VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein.

Applications: COVID-19-immunoregulation

Formula: C24H18F2N2O5

References: [1]Van Goor F, et al. Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809. Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18843-8./[2]Phuan PW, et al. Synergy-based small-molecule screen using a human lung epithelial cell line yields ΔF508-CFTR correctors that augment VX-809 maximal efficacy. Mol Pharmacol. 2014 Jul;86(1):42-51.

CAS Number: 936727-05-8

Molecular Weight: 452.41

Compound Purity: 99.85

Research Area: Inflammation/Immunology

Solubility: DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Autophagy;CFTR

• SKU: MEXHY-13262-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-13262-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK