Product Description: Lupenone is an orally active lupine-type triterpenoid that can be isolated from Musa basjoo. Lupenone Lupenone plays a role through the PI3K/Akt/mTOR and NF-κB signaling pathways. Lupenone has anti-inflammatory, antiviral, antidiabetic and anticancer activities[1][2][3].
Applications: Cancer-programmed cell death
Formula: C30H48O
References: [1]Lee HS, et al. Lupenone Protects Neuroblastoma SH-SY5y Cells Against Methamphetamine-Induced Apoptotic Cell Death via PI3K/Akt/mTOR Signaling Pathway. Int J Mol Sci. 2020 Feb 27;21(5):1617./[2]Wu H, et al. Lupenone improves type 2 diabetic nephropathy by regulating NF-κB pathway-mediated inflammation and TGF-β1/Smad/CTGF-associated fibrosis. Phytomedicine. 2023 Sep;118:154959./[3]Mukerjee N, et al. Dynamics of natural product Lupenone as a potential fusion inhibitor against the spike complex of novel Semliki Forest Virus. PLoS One. 2022 Feb 25;17(2):e0263853.
CAS Number: 1617-70-5
Molecular Weight: 424.70
Compound Purity: 99.74
Research Area: Cancer; Infection; Inflammation/Immunology
Solubility: Ethanol : 10 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Akt;mTOR;NF-κB;Parasite;PI3K
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