Shelf life (days): 730.0
Formulation: A crystalline solid
Formal Name: (6'R)-ß,e-carotene-3R,3'R-diol
Purity: ≥98%
Formula Markup: C40H56O2
Formula Weight: 568.9
CAS Number: 127-40-2
Notes: Lutein is a dietary carotenoid that has been found in eggs and yellow-colored fruits and vegetables and has diverse biological activities.{56228,56230,56229,56231} It reduces hyperglycemia-induced mitochondrial DNA damage and production of reactive oxygen species (ROS) and promotes mitochondrial biogenesis in ARPE-19 cells when used at a concentration of 10 µM.{56228} Lutein (20 mg/kg) increases nitric oxide (NO) production and decreases serum levels of endothelin-1 (Item No. 24127) in a rat model of hyperhomocysteinemia.{56230} Dietary administration of lutein (0.2%) decreases monocyte migration and lesion size in an ApoE-/- and Ldlr-/- mouse models of atherosclerosis. Lutein reduces infarct size and cardiac malondialdehyde (MDA), lactate dehydrogenase (LDH), and troponin T levels, and increases cardiac levels of catalase (CAT), superoxide dismutase (SOD), heme oxygenase-1 (HO-1), and Nrf2 in a rat model of heart failure induced by isoproterenol (Item No. 15592).{56229} It forms a retinal pigment in human eyes, and high dietary intake of lutein is positively correlated with reduced risk of age-related macular degeneration and cataracts in humans.{56231}
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