Product Description: Luxdegalutamide (ARV-766) is an orally active protein hydrolysis targeted chimeric (PROTAC) targeting androgen receptor (AR), which can degrade AR resistance related mutants, including T878/H875/L702 mutants. Luxdegalutamide has anti-tumor activity and can be used in the study of castration resistant prostate cancer[1][2].
Applications: Cancer-programmed cell death
Formula: C45H54FN7O6
References: [1]Snyder L, et al. In vitro evaluation of PROTAC® degrader ARV-766 for cytochrome P450-and transporter-mediated drug-drug interaction[J]. Drug Metabolism and Pharmacokinetics, 2024, 55: 100881./[2]Snyder L, et al. Abstract ND03: Discovery of ARV-766, an androgen receptor degrading PROTAC® for the treatment of men with metastatic castration resistant prostate cancer[J]. Cancer Research, 2023, 83(7_Supplement): ND03-ND03.
CAS Number: 2750830-09-0
Molecular Weight: 807.95
Compound Purity: 98.94
Research Area: Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: Androgen Receptor;PROTACs
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