LXE408, CAS 1799330-15-6

Product Description: LXE408 is an orally active, non-competitive and kinetoplastid-selective proteasome inhibitor. LXE408 has an IC50 of 0.04 μM for L. donovani proteasome and an EC50 of 0.04 μM for L. donovani. LXE408 has a low propensity to cross the blood brain barrier. LXE408 has the potential for visceral leishmaniasis (VL) research[1].

Applications: COVID-19-immunoregulation

Formula: C23H18FN7O2

References: [1]Advait Nagle, et al. Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases. J Med Chem. 2020 Jul 15.

CAS Number: 1799330-15-6

Molecular Weight: 443.43

Compound Purity: 99.08

Research Area: Infection

Solubility: DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Parasite;Proteasome

• SKU: MEXHY-131350-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-131350-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK