Product Description: LY310762 is a selective 5-HT1D receptor antagonist (Ki=249 nM) with a weak affinity for 5-HT1B receptor. LY310762 effectively abolishes the renal vasodilatory effects of 5-HTSumatriptan (HY-B0121B)-induced decrease in excitatory postsynaptic potential (EPSC) amplitude[1][2][3].
Applications: Neuroscience-Neuromodulation
Formula: C24H28ClFN2O2
References: [1]Pullar IA, et al. The role of the 5-HT1D receptor as a presynaptic autoreceptor in the guinea pig. Eur J Pharmacol. 2004 Jun 16;493(1-3):85-93. /[2]García-Pedraza JÁ, et al. Pharmacological evidence that 5-HT1D activation induces renal vasodilation by NO pathway in rats. Clin Exp Pharmacol Physiol. 2015 Jun;42(6):640-7. /[3]Choi IS, Cho JH, An CH, Jung JK, Hur YK, Choi JK, Jang IS. 5-HT(1B) receptors inhibit glutamate release from primary afferent terminals in rat medullary dorsal horn neurons. Br J Pharmacol. 2012 Sep;167(2):356-67.
CAS Number: 192927-92-7
Molecular Weight: 430.94
Compound Purity: 98.68
Research Area: Neurological Disease; Cardiovascular Disease
Solubility: DMSO : 18.33 mg/mL (ultrasonic)
Target: 5-HT Receptor
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