Product Description: LY3154207 is a potent, subtype selective, and orally available human dopamine D1 receptorpositive allosteric modulator (PAM) with minimal allosteric agonist activity (EC50=3 nM)[1].
Applications: Neuroscience-Neuromodulation
Formula: C24H29Cl2NO3
References: [1]Hao J, Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor. J Med Chem. 2019 Oct 10;62(19):8711-8732.
CAS Number: 1638667-79-4
Molecular Weight: 450.40
Compound Purity: 99.87
Research Area: Neurological Disease
Solubility: DMSO : 110 mg/mL (ultrasonic)
Target: Dopamine Receptor