LY3214996, CAS 1951483-29-6

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 5,6-dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-4H-thieno[2,3-c]pyrrol-4-one

Purity: ≥98%

Formula Markup: C22H27N7O2S

Formula Weight: 453.56176

CAS Number: 1951483-29-6

Notes: LY3214996 is an inhibitor of ERK1 and ERK2 (IC50 = 5 nM for both).{42884} It inhibits cell proliferation of tumor cells in vitro, including those expressing B-RAF, N-Ras, or K-Ras mutations. LY3214996 inhibits tumor growth in B-RAF or N-Ras mutant melanoma, B-RAF or K-Ras mutant colorectal, lung, and pancreatic cancer mouse xenograft models, as well as patient-derived xenograft (PDX) mouse models.

• SKU: CAY27936-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 27936-25
• Package Unit: 25 mg
• Quantity Unit: STK