LY456236 (hydrochloride), CAS 338736-46-2

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 6-methoxy-N-(4-methoxyphenyl)-4-quinazolinamine, monohydrochloride

Purity: ≥98%

Formula Markup: C16H15N3O2 / HCl

Formula Weight: 317.8

CAS Number: 338736-46-2

Notes: An antagonist of mGluR1 (IC50 = 140 nM); reduces the growth of PC-9 cells and PC-9-AMG cells in MGS co-culture but not in monoculture; reduces MGS co-culture-induced increases in EGFR levels in PC-9-AMG cells; reduces tumor growth in a PC-9-AMG mouse model of brain metastasis at 50 mg/kg per day; inhibits seizures in a variety of seizure models, including inhibition of audiogenic clonic-tonic seizures in mice (ED50 = 35 mg/kg); reduces second-phase, but not first-phase, formalin-induced hyperalgesia at 30 and 100 mg/kg

• SKU: CAY42263-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42263-25
• Package Unit: 25 mg
• Quantity Unit: STK