LYP-8

Product Description: LYP-8 is a potent and effective NAMPT degrader with maximum degradation of 97% at 0.5 μM in SKOV-3 cells. LYP-8 shows anti-cancer activity in vivo and in vitro(Sturcture Note:(Blue: Cereblon ligand (HY-112078), Black: linker (HY-128801)；Pink: Nampt inhibitor Nampt-IN-11 (HY-158689))[1].

Applications: Cancer-programmed cell death

Formula: C56H74N8O10S

References: [1]Lu T, et al. Design of FK866-Based Degraders for Blocking the nzymatic Functions of Nicotinamide Phosphoribosyltransferase. J Med Chem. 2024;67(10):8099-8121.

Molecular Weight: 1051.30

Compound Purity: 99.89

Research Area: Cancer

Target: NAMPT;PROTACs

• SKU: MEXHY-162537-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-162537-5
• Package Unit: 5 mg
• Quantity Unit: STK