M40 acetate(143896-17-7 free base)

Description: M40 acetate is a potent, non-selective galanin receptor antagonist (Ki values are 1.82 and 5.1 nM at GAL1 and GAL2 respectively) that inhibits galanin (1-29) binding in rat brain in vitro (IC50 = 3 - 15 nM). Attenuates the antidepressant effects of fluoxetine and blocks galanin-induced food intake in vivo. Also exhibits weak partial agonist activity at peripheral GAL2 receptors at doses > 100 nM.

Formula: C96H149N23O26

Molecular Weight: 2041,38

References: Lu et al (2005) A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus. Proc.Natl.Acad.Sci.USA 102 874

• SKU: TGMTP1992L-200mg
• Manufacturer: TargetMol Chemicals
• Manufacturer SKU: TP1992L-200mg
• Package Unit: 200 mg
• Quantity Unit: STK