Macozinone, CAS 1377239-83-2

Product Description: Macozinone (PBTZ169) is a bactericidal benzothiazinone and a potent DprE1 (decaprenylphosphoryl-β-d-ribose 2′-oxidase) inhibitor. Macozinone inhibits the essential flavoprotein DprE1 by forming a covalent bond with the active-site Cys387 residue. Macozinone has antituberculosis effect[1][2].

Applications: Cancer-programmed cell death

Formula: C20H23F3N4O3S

References: [1][3] Makarov V et al. Towards a new combination therapy for tuberculosis with next generation benzothiazinones. EMBO Mol Med. 2014 Mar;6(3):372-83.

CAS Number: 1377239-83-2

Molecular Weight: 456.48

Compound Purity: 98.46

Research Area: Infection

Solubility: DMSO : 6.4 mg/mL (ultrasonic)

Target: Antibiotic;Bacterial

• SKU: MEXHY-12903-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-12903-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK