MAP4K4-IN-3, CAS 1811510-58-3

Product Description: MAP4K4-IN-3 (Compound 17) is a potent and selective MAP4K4 inhibitor with an IC50 of 14.9 nM in kinase assay, an IC50 of 470 nM in cell assay. Antidiabetic agent[1].

Applications: Metabolism-protein/nucleotide metabolism

Formula: C15H12ClN5

References: [1]Ammirati M, et al. Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based AntidiabeticTreatment. ACS Med Chem Lett. 2015 Oct 6;6(11):1128-33./[2]Dow RL, et al. 2-Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety. J Med Chem. 2018 Apr 12;61(7):3114-3125.

CAS Number: 1811510-58-3

Molecular Weight: 297.74

Compound Purity: 99.15

Research Area: Metabolic Disease

Solubility: DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)

Target: MAP4K

• SKU: MEXHY-125012-200
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-125012-200
• Package Unit: 200 mg
• Quantity Unit: STK