Mavrilimumab, CAS 1085337-57-0

Mavrilimumab, CAS 1085337-57-0
SKU
MEXHY-P99031-25
Packaging Unit
25 mg
Manufacturer
MedChemExpress

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Product Description: Mavrilimumab (CAM 3001) is a monoclonal antibody that binds to the α subunit of the granulocyte-macrophage colony stimulating factor (GM-CSF) receptor and blocks intracellular signalling downstream of GM-CSF. GM-CSF might be a mediator of the hyperactive inflammatory response associated with respiratory failure and death[1].

Applications: COVID-19-immunoregulation

Formula: N/A

References: [1]Paul C Cremer, et al. Mavrilimumab in patients with severe COVID-19 pneumonia and systemic hyperinflammation (MASH-COVID): an investigator initiated, multicentre, double-blind, randomised, placebo-controlled trial. Lancet Rheumatol. 2021 Jun;3(6):e410-e41/[2]Ryan PC, et al., Nonclinical safety of mavrilimumab, an anti-GMCSF receptor alpha monoclonal antibody, in cynomolgus monkeys: relevance for human safety. Toxicol Appl Pharmacol. 2014 Sep 1;279(2):230-9.

CAS Number: 1085337-57-0

Molecular Weight: (143.168 kDa)

Compound Purity: 98.37

Research Area: Inflammation/Immunology; Cardiovascular Disease

Solubility: H2O

Target: c-Fms
More Information
SKU MEXHY-P99031-25
Manufacturer MedChemExpress
Manufacturer SKU HY-P99031-25
Package Unit 25 mg
Quantity Unit STK
Conjugate Unconjugated
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