MBM-55, CAS 2083622-09-5

Product Description: MBM-55 is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 1 nM. MBM-55 shows a 20-fold or greater selectivity in most kinases with the exception of RSK1 (IC50=5.4 nM) and DYRK1a (IC50=6.5 nM). MBM-55 effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-55 shows antitumor activities, and no obvious toxicity to mice[1].

Applications: Cancer-Kinase/protease

Formula: C28H27FN6O2

References: [1]Xi JB, et al. Structure-based design and synthesis of imidazo[1,2-a]pyridine derivatives as novel and potent Nek2 inhibitors with in vitro and in vivo antitumor activities. Eur J Med Chem. 2017 Jan 27;126:1083-1106.

CAS Number: 2083622-09-5

Molecular Weight: 498.55

Compound Purity: 99.94

Research Area: Cancer

Solubility: DMSO : 125 mg/mL (ultrasonic)

Target: Apoptosis;NEKs

• SKU: MEXHY-101029-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-101029-5
• Package Unit: 5 mg
• Quantity Unit: STK