MBP146-78, CAS 188343-77-3

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 4-[2-(4-fluorophenyl)-5-(1-methyl-4-piperidinyl)-1H-pyrrol-3-yl]-pyridine

Purity: ≥98%

Formula Markup: C21H22FN3

Formula Weight: 335.4

CAS Number: 188343-77-3

Notes: MBP146-78 is an inhibitor of parasitic cGMP-dependent protein kinases (PKGs; IC50s = 1.9 and 1 nM for the E. tenella and T. gondii enzymes, respectively).{67818} It inhibits P. berghei sporozoite development into liver-stage parasites in HepG2 cells in a concentration-dependent manner.{67819} MBP146-78 (50 mg/kg) prevents P. yoelii liver infection in P. yoelii-infected mice. It increases survival time in P. berghei-infected mice when administered at a dose of 50 mg/kg twice per day for eight days.{67818} MBP146-78 (50 mg/kg two times per day) increases survival in T. gondii-infected mice and prevents secondary reinfection in the same mice.{67820}

• SKU: CAY41083-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41083-5
• Package Unit: 5 mg
• Quantity Unit: STK