MCUF-651, CAS 2747162-85-0

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: N-(4,6-difluoro-2-benzothiazolyl)-1-[2-(dimethylamino)ethyl]-3-piperidinecarboxamide

Purity: ≥98%

Formula Markup: C17H22F2N4OS

Formula Weight: 368.445746

CAS Number: 2747162-85-0

Notes: A GC-A positive allosteric modulator; induces the production of cGMP in the presence (EC50 = 0.45 µM) but not the absence of ANP in HEK293 cells expressing human GC-A; selective for GC-A over GC-B in HEK293 cells expressing the human receptors at 10 µM; binds to the GC-A extracellular domain (Kd = 397 nM) and enhances the binding of ANP to the GC-A extracellular domain in cell-free assays; enhances ANP-induced production of cGMP in primary human renal proximal tubular cells, visceral adipocytes, and cardiomyocytes from 1-10 µM; inhibits TGF-ß1-induced hypertrophy of primary human cardiomyocytes in combination with ANP; induces cGMP production in GC-A-expressing HEK293 cells incubated with plasma isolated from patients with hypertension or heart failure

• SKU: CAY42055-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42055-10
• Package Unit: 10 mg
• Quantity Unit: STK