Target: MDC1
Conjugate: HRP
Product Type: Monoclonal
Clone Number: P2B11
Immunogen: GST-tagged recombinant protein corresponding to mouse MDC1 at and around the N-terminus
Swiss-Prot: Q5PSV9
Purification: Protein G Purified
Storage Buffer: 73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide and 0.23mM Citrate in dH2O
Concentration: 1 mg/ml
Specificity: Detects ~184kDa. This antibody recognizes MDC1 at and around the N-terminus.
Cellular Localization: Nucleus
Scientific Background: MDC1, mediator of DNA damage checkpoint protein 1, plays a role in checkpoint mediated cell cycle arrest in response to DNA damage, within S phase and G2/M. It is also thought to act as a scaffold protein during recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage that are marked by phosphorylation of histone H2A.X on S139.
References: 1. Lou Z., et al. (2004) J Biol Chem. 279(45): 46359-46362.2. Luo K., Yuan J, Lou Z. (2011) J Biol Chem. 286(32): 28192-28199.3. Strauss C., Halevy T., Macarov M., Argaman L., and Goldbery M. (2011) DNA Repair (Amst.). 10(8): 806-814.4. Wilson K.A., et al. (2011) Mol Cancer Res. 9(6): 766-781.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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