MDH1/2-IN-1, CAS 2143473-95-2

Product Description: MDH1/2-IN-1 is a MDH1/2 inhibitor (IC50: 1.07 nM and 1.06 nM respectively). MDH1/2-IN-1 inhibits mitochondrial respiration and the HIF-1α pathway. MDH1/2-IN-1 demonstrates significant anti-tumor potential. MDH1/2-IN-1 provides a new direction for the development of drugs targeting cancer metabolism[1].

Applications: Cancer-Kinase/protease

Formula: C25H33NO4

References: [1]Naik R, et al. Methyl 3-(3-(4-(2,4,4-Trimethylpentan-2-yl)phenoxy)-propanamido)benzoate as a Novel and Dual Malate Dehydrogenase (MDH) 1/2 Inhibitor Targeting Cancer Metabolism. J Med Chem. 2017 Oct 26;60(20):8631-8646.

CAS Number: 2143473-95-2

Molecular Weight: 411.53

Research Area: Cancer

Target: HIF/HIF Prolyl-Hydroxylase;Malate Dehydrogenase (MDH);Mitochondrial Metabolism

• SKU: MEXHY-W613220-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-W613220-0
• Package Unit: Get quote
• Quantity Unit: STK