Product Description: MDL-29951 is a novel glycine antagonist of NMDA receptor activation, with Ki of 0.14 μM for [3H]glycine binding in vitro and in vivo.
Applications: Neuroscience-Neurodegeneration
Formula: C12H9Cl2NO4
References: [1]Baron BM, et al. Potent indole- and quinoline-containing N-methyl-D-aspartate antagonists acting at the strychnine-insensitive glycine binding site. J Pharmacol Exp Ther. 1992 Sep;262(3):947-56./[2]Wright SW, et al. 3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site. Bioorg Med Chem Lett. 2003 Jun 16;13(12):2055-8./[3]Harden TK. Enigmatic GPCR finds a stimulating drug. Sci Signal. 2013 Oct 22;6(298):pe34.
CAS Number: 130798-51-5
Molecular Weight: 302.11
Compound Purity: 99.17
Research Area: Neurological Disease
Solubility: DMSO : ≥ 50 mg/mL
Target: iGluR
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