Product Description: Mefenidil (MCN 2378) is a selective cerebral vasodilator that is not affected by beta-adrenergic blockade. Mefenidil can be used in the study of cardiovascular disease. In monkey models, mefenidil preferentially increases cerebral blood flow over systemic (femoral) blood flow. Mefenidil is also able to reduce systemic arterial pressure in anesthetized dogs.
Applications: Neuroscience-Neuromodulation
Formula: C12H11N3
References: [1]Hageman WE, et al. Cardiovascular profile of 5-methyl-2-phenyl-4-imidazole-acetonitrile (MCN-2378), a cerebral vasodilator. Eur J Pharmacol. 1975 Jan;30(1):100-6./[2]Cardiovascular profile of 5-methyl-2-phenyl-4-imidazole-acetonitrile (MCN-2378), a cerebral vasodilator
CAS Number: 58261-91-9
Molecular Weight: 197.24
Research Area: Cardiovascular Disease
Solubility: 10 mM in DMSO
Target: Adrenergic Receptor
English
Deutsch
