Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 3-(2-methoxyphenoxy)-1,2-propane-1,1,2,3,3-d5-diol, 1-carbamate
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C11H10D5NO5
Formula Weight: 246.27084
CAS Number: 1189699-70-4
Notes: Methocarbamol-d5 is intended for use as an internal standard for the quantification of methocarbamol (Item No. 23870) by GC- or LC-MS. Methocarbamol is an orally bioavailable skeletal muscle relaxant.{38705} In vivo, methocarbamol inhibits the ability of mice to remain on a vertical ladder for 1 minute (ED50 = 15 mg/kg) and decreases forelimb grip strength by 35.9% when administered at a dose of 500 mg/kg.{38705,38707} It abolishes femoral nerve-stimulated polysynaptic reflex contractions of the cat tibialis anterior muscle and prolongs the mean refractory period of directly or indirectly stimulated skeletal muscle when administered at a dose of 200 mg/kg.{38708} Methocarbamol also selectively inhibits human carbonic anhydrase (CA) isoform I over CAII (IC50s = 70 and ~80,000 μM, respectively).{38706} Formulations containing methocarbamol have been used to treat skeletal muscle spasms.
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