Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: (3R)-3-(1,3-benzodioxol-5-ylmethyl)-2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-4H-1-benzopyran-4-one
Purity: ≥98%
Formula Markup: C19H18O6
Formula Weight: 342.34262
CAS Number: 74805-92-8
Notes: Methylophiopogonanone A is a homoisoflavonoid that has been found in O. japonicus roots and has diverse biological activities.{49616,49617,49618,49619} It increases the uptake of rosuvastatin (Item Nos. 12029 / 18813) and atorvastatin (Item No. 10493) in HEK293T cells expressing human organic anion transporting polypeptide 1B1 (OATP1B1; EC50s = 11.33 and 6 µM, respectively).{49617} Methylophiopogonanone A scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and ABTS (Item No. 27317) radicals in cell-free assays.{49616} In vivo, methylophiopogonanone A (10 mg/kg) decreases body weight gain and reduces serum and hepatic lipid levels in a rat model of high-fat diet-induced hyperlipidemia.{49618} It also reduces infarct size and myocardial apoptosis in mouse model of ischemia-reperfusion injury induced by transient occlusion of the left anterior descending coronary artery.{49619}
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