Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2-methyl-1,2-di-3-pyridinyl-1-propanone
Purity: ≥98%
Formula Markup: C14H14N2O
Formula Weight: 226.3
CAS Number: 54-36-4
Notes: Metyrapone is an inhibitor of the cytochrome P450 (CYP) enzyme 11β-hydroxylase (IC50 = 7.83 µM), an enzyme involved in the final step of cortisol biosynthesis.{24101} It also induces Cyp1a1 and Cyp3a4 expression in rat hepatic microsomes and inhibits the activity of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in sheep liver microsomes.{24100,24099,65053} Metyrapone (150 mg/kg, s.c.) suppresses hypoxia-ischemia-induced increases in plasma corticosterone levels and seizures in rats.{65054} It also reduces ethanol consumption in alcohol high-preferring rats.{65055} Formulations containing metyrapone have been used in the diagnosis of adrenal insufficiency and the treatment of Cushing’s disease.
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