Product Description: Mexiletine is an orally effective antiarrhythmic agent which has also been found to be effective for myotonia and neuropathic pain. Mexiletine exerts its efficacy through blocking sodium channels (IC50 : 75±8 μM for tonic block, 23.6±2.8 μM for use-dependent block), therefore can be used for cardiovascular and neurological research[1][2][3][4][5].
Formula: C11H17NO
References: [1]Campbell RW, et al. Mexiletine. N Engl J Med. 1987，316(1):29-34./[2]De Bellis M, et al. Combined modifications of mexiletine pharmacophores for new lead blockers of Na(v)1.4 channels. Biophys J. 2013，104(2):344-54./[3]Nasilli G, et al. Mexiletine reverses oxaliplatin-induced neuropathic pain in rats. J Pharmacol Sci. 2010;112(4):473-6./[4]Egashira N, et al. Mexiletine reverses oxaliplatin-induced neuropathic pain in rats. J Pharmacol Sci. 2010，112(4):473-6.
CAS Number: 31828-71-4
Molecular Weight: 179.26
Compound Purity: 99.92
Research Area: Neurological Disease; Cardiovascular Disease
Solubility: DMSO : ≥ 175 mg/mL
Target: Sodium Channel
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