Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 3-(5-methyl-1,3,4-thiadiazol-2-yl)-6-[4-[2-(trifluoromethyl)phenoxy]-1-piperidinyl]-pyridazine
Purity: ≥98%
Formula Markup: C19H18F3N5OS
Formula Weight: 421.4
CAS Number: 921605-87-0
Notes: MF438 is an inhibitor of stearoyl-CoA desaturase 1 (SCD1; IC50 = 2.3 nM for the rat enzyme), an enzyme that catalyzes the formation of a cis double bond at the ∆9 position of stearoyl-CoA to produce oleoyl-CoA.{62042,62043} It reduces spheroid formation in NCI H460 and patient-derived non-small cell lung cancer (NSCLC) cells in a concentration-dependent manner, an effect that can be blocked by oleic acid (Item Nos. 90260 / 24659).{62044} MF438 (1 µM) decreases the activity of aldehyde dehydrogenase 1A1 (ALDH1A1), a marker of cancer stem cells (CSCs), in NCI H460-derived spheroids when used at a concentration of 1 µM. It acts synergistically with cisplatin (Item No. 13119) to induce apoptosis and autophagy in patient-derived NSCLC cells.{62045}
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