MHES0488A

Product Description: MHES0488A is a selective humanized antibody that targets HER2 with a KD value of 0.8 nM. MHES0488A is an antibody part of DHES0815A. MHES0488A is internalized by cells and transported to lysosomes, and then releases PBD-monoamide that enters the nucleus, alkylates DNA and induces DNA damage and apoptosis. MHES0488A is promising for research of cancers, such as HER2-positive breast cancer and gastric cancer[1].

Formula: N/A

References: [1]Lewis G, et al. Development of DHES0815A; a novel HER2-directed antibody-drug conjugate comprised of a reduced potency mono-alkylating agent linked to a domain I binding HER2 antibody[J]. 2022.

Molecular Weight: N/A

Research Area: Cancer

Target: DNA Alkylator/Crosslinker;EGFR

• SKU: MEXHY-P991236-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-P991236-0
• Package Unit: Get quote
• Quantity Unit: STK
• Conjugate: Unconjugated