Product Description: Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1].
Applications: Cancer-programmed cell death
Formula: C29H35NO2
References: [1]Jiang W, et al. New progesterone receptor antagonists: phosphorus-containing 11beta-aryl-substituted steroids. Bioorg Med Chem. 2006 Oct 1;14(19):6726-32./[2]Jurado R, et al. NSC 119875 cytotoxicity is increased by mifepristone in cervical carcinoma: an in vitro and in vivo study. Oncol Rep. 2009 Nov;22(5):1237-45./[3]Sharrett-Field L, et al. Mifepristone Pretreatment Reduces Ethanol Withdrawal Severity In Vivo. Alcohol Clin Exp Res. 2013 Aug;37(8):1417-23./[4]Yuehua You, et al. Progesterone Promotes Endothelial Nitric Oxide Synthase Expression Through Enhancing Nuclear Progesterone receptor-SP1 Formation. Am J Physiol Heart Circ Physiol. 2020 Jul 3.
CAS Number: 84371-65-3
Molecular Weight: 429.59
Compound Purity: 99.83
Research Area: Endocrinology; Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Autophagy;Endogenous Metabolite;Glucocorticoid Receptor;NO Synthase;Progesterone Receptor
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