(E/Z)-Mirin, CAS 299953-00-7

Product Description: Mirin is a potent Mre11-Rad50-Nbs1 (MRN) complex inhibitor. Mirin prevents MRN-dependent activation of ATM (IC50=12 μM) without affecting ATM protein kinase activity, and it inhibits Mre11-associated exonuclease activity. Mirin abolishes the G2/M checkpoint and homology-dependent repair in mammalian cells. Mirin prevents ATM activation in response to DNA double-strand breaks (DSBs) and blocks homology-directed repair (HDR) in mammalian cells[1].

Applications: Cancer-Kinase/protease

Formula: C10H8N2O2S

References: [1]Dupré A, et al. A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat Chem Biol. 2008;4(2):119-125./[2]Ying S, et al. Mre11-dependent degradation of stalled DNA replication forks is prevented by BRCA2 and PARP1. Cancer Res. 2012;72(11):2814-2821.

CAS Number: 299953-00-7

Molecular Weight: 220.25

Compound Purity: 98.12

Research Area: Cancer

Solubility: DMSO : 83.33 mg/mL (ultrasonic)

Target: ATM/ATR

• SKU: MEXHY-117693-100
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-117693-100
• Package Unit: 100 mg
• Quantity Unit: STK