Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1aS,2,8S,8aR,8bS-hexahydro-8a-methoxy-5-methyl-azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione
Purity: ≥98%
Formula Markup: C15H18N4O5
Formula Weight: 334.3
CAS Number: 50-07-7
Notes: Mitomycin C (MMC) is an antitumor antibiotic that was discovered as a fermentation product of S. caespitosus.{20830} As an alkylating agent, its activity depends on reductive activation either through low pH or DT-diaphorase or NADH cytochrome c reductase.{20829} Activated MMC crosslinks double stranded DNA and is widely used as a tool to selectively inhibit DNA synthesis and mutagenensis, to stimulate genetic recombination, chromosome breakage and sister chromatid exchange, and to induce DNA repair.{20826,20827} MMC has clinical significance in combination cancer chemotherapy of solid tumors as well as for modulating wound healing after ophthalmological surgeries and in the management of various corneal disorders.{20828,20831}
English
Deutsch
