Product Description: MitoTam bromide, hydrobromide, a Tamoxifen derivative[1], is an electron transport chain (ETC) inhibitor. MitoTam bromide, hydrobromide reduces mitochondrial membrane potential in senescent cells and affects mitochondrial morphology[2]. MitoTam bromide, hydrobromide is an effective anticancer agent, suppresses respiratory complexes (CI-respiration) and disrupts respiratory supercomplexes (SCs) formation in breast cancer cells[1][2].
Applications: Cancer-programmed cell death
Formula: C52H60Br2NOP
References: [1]Rohlenova K, et al. Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2highBreast Cancer. Antioxid Redox Signal. 2017 Jan 10;26(2):84-103./[2]Hubackova S, et al. Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2. Cell Death Differ. 2019 Jan;26(2):276-290.
CAS Number: 1634624-73-9
Molecular Weight: 905.82
Compound Purity: 98.24
Research Area: Cancer
Solubility: DMSO : 240 mg/mL (ultrasonic)
Target: Apoptosis;Mitochondrial Metabolism
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