Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]-benzene
Purity: ≥98%
Formula Markup: C14H10Cl4
Formula Weight: 320.0
CAS Number: 53-19-0
Notes: Mitotane is an inhibitor of steroidogenesis.{30365} It decreases secretion of cortisol (Item No. 20739) and 17-hydroxy progesterone (Item No. 33154) from H295R adrenocortical carcinoma cells when used at a concentration of 50 µM. Mitotane also inhibits mitochondrial complex IV, also known as cytochrome c oxidase, activity in H295R cells (IC50 = 58 µM). It inhibits steroid production induced by adrenocorticotropic hormone (ACTH) and is cytotoxic to zona fasciculata and zona reticularis, but not zona glomerulosa, adrenal cortex cells in dogs when administered at a dose of 60 mg/kg.{64392} Formulations containing mitotane have been used in the treatment of adrenocortical carcinoma.
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